Preparation and Evaluation of Chewable Tablets of Syzygium cumini Seed Powder

Aim of this study is to develop chewable tablets of Syzygium cumini seed powder. It has been chosen to do so as there are no oral solid dosage forms of this seed powder developed so far. There are numerous health benefits and nutrient properties of this seed powder, thus it can be used as a nutraceutical. Phytochemical screening of the Syzygium cumini seed powder has been conducted and the various phyto constituents present were detected. Seven different formulations have been developed by direct compression method out of which five were optimized. All these formulations were developed with Syzygium cumini seed powder as the active ingredient and lactose, acacia, glucose, talc, magnesium stearate, hydroxy propyl methyl cellulose, sodium alginate, guar gum and stevia were used as excipients. Various evaluations tests were performed to check the stability of the chewable tablets. Fourier Transform Infrared Spectroscopy (FTIR) analysis was conducted to check the interactions among the seed powder and the excipients. Anti-bacterial activity of the chewable tablets was tested against three different species of bacteria (Escherichia coli and Bacillus subtilis) by agar diffusion method. It is concluded that the Syzygium cumini seed powder and the developed chewable tablets were active against Escherichia coli and Bacillus subtilis.     Keywords: Syzygium cumini, Chewable tablet, anti-bacterial activit

Preparation and Evaluation of Oral Thin Films of a Natural Product: Syzygium cumini seed powder

Aim of this project is to develop oral thin films of Syzygium cumini seed powder. Though there were chewable tablets of Syzygium cumini reported in the literature, it has been chosen to formulate oral thin films of Syzygium cumini seed powder as they are expected to be more accepted by pediatrics, over the chewable tablets. Because of its high health benefits, these dosage forms have a potential to be nutraceuticals. Various phyto constituents present in the Syzygium cumini seed powder were screened through phytochemical screening. Four different formulations of oral thin films have been developed out of which two were optimized. Oral thin films were formulated with Syzygium cumini as the active ingredient and hydroxy propyl methyl cellulose, sodium alginate, glucose, guar gum, stevia, polyethylene glycol, water and dichloromethane were used as excipients. Different evaluation studies were performed for the oral thin films. Fourier Transform Infrared Spectroscopy (FTIR) analysis was performed for the oral thin films to check the interactions between the active ingredients and the excipients. Antibacterial activity of the oral thin films was performed against two different bacterial species viz, Escherichia coli and Bacillus subtilis. It is concluded that the developed oral thin films were depicting antibacterial activity. Keywords: Syzygium cumini, oral films, natural product, nutraceuticals, anti-bacterial activit